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Expert in Bioinformatics, Computational and Systems Biology
Available for your Consulting and Expert Witness Needs
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Summary of Expertise:
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Listed with other top experts in: |
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Expert is a bioinformatician with extensive international experience in computational and structural biology. With his formal training in molecular biophysics, he has over thirty years academic and industrial experience working at the interface of the mathematical and physical sciences and molecular biology. His early research contributions, in the field of structural biology, include the development of experimental and computational methods for macromolecular structure determination, including the solution of the first protein structure to be solved using synchrotron radiation techniques, now used a standard method in structural genomics. He also spent part of his career in industry, with Allelix Biopharmaceuticals, Oxford Molecular and GlaxoWellcome, where he played a leading role in the development of distributed object environments for the analysis, integration and visualization of bioinformatics data and was an early adopter of work flow languages for biocomputing applications. Since the mid-1990's, he has developed a productive research programme in the field of statistical
bioinformatics, which focuses on the application of state-of-the-art Bayesian methods emerging from the statistical machine learning community to a variety of problems in systems biology, functional genomics and proteomics. His recent work has included the use of state-space models to reverse engineer transcriptional networks from highly replicated gene expression microarray time series data, using statistically robust methods for model selection and parameter estimation; the application of nonparametric Bayesian techniques for solving clustering, feature selection and classification problems in bioinformatics data, and the development of hidden Markov and semi-Markov models for protein remote homolog recognition and secondary structure prediction. In the field of computational structural biology his current research focuses on the use of statistical machine learning and Bayesian computation to analyse protein energetics and the energy landscape of protein folding simulations.
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Show Secondary and Basic Areas of Expertise |
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Degree |
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Subject |
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Institution |
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2009
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MSc
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Mathematics
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Open University, UK
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1982
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PhD
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Molecular Biophysics
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University of Oxford, UK
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1977
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MPhil
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Biostatistics
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Council for National Academic Awards, UK
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1974
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BA
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Physics
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University of York, UK
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Department |
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Title |
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2006 to
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(Undisclosed University)
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Systems Biology Centre
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Professor of Bioinformatics
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Performs research in bioinformatics and computational systems biology.
Teaches postgraduate courses in statistical bioinformatics and modelling and statistics in systems biology.
Supervises bioinformatics and scientific computing support team.
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1999 to 2006
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Keck Graduate Institute of Applied Life Sciences, USA
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Associate Professor and Director of Computing
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Research in bioinformatics and computational systems biology.
Developed and taught the computational biology and bioinformatics component of a pioneering professional masters degree aimed at preparing future leaders in the bioscience industry.
Developed and managed institute's research computing infrastructure.
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1997 to 1999
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Oxford Molecular and Glaxo Wellcome Medicines Research Centre, UK
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Bioinformatics Group
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Senior Bioinformatics Analyst
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Research in and software development for protein bioinformatics.
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1994 to 1997
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The Salk Institute for Biological Studies, USA
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Structural Biology Laboratory
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Senior Staff Scientist
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Software development for structural molecular biology. Managed laboratory's research computing infrastructure.
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1989 to 1994
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European Molecular Biology Laboratory, Germany
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Biological Structures and Biocomputing
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Staff Scientist
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Software development for macromolecular crystallography.
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1987 to 1989
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Allelix Biopharmaceuticals Inc., Canada
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Senior Research Scientist
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Research in stucture-based drug design.
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1984 to 1987
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European Molecular Biology Laboratory, France
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Staff Scientist
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Research in structural molecular biology. Managed laboratory's research computing infrastructure.
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1982 to 1984
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University of Nottingham, UK
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Department of Applied Biochemistry
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Research Fellow
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Research in structural molecular biology.
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| Publications: |
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Publications and Patents Summary
He has published over 40 peer-reviewed publications and several invited chapters in edited volumes.
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Selected Publications and Publishers
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- Bioinformatics
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- Biophysical Journal
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| Selected Consulting Examples: |
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He has consulted in the biotechnology sector on problems relating to protein sequence analysis.
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Expert for a free initial screening call regarding your expert consulting needs.
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| Language Skills: |
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| Foreign Language |
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Description |
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French
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Advanced
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German
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Advanced
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| Additional Skills and Services: |
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Training/Seminars
In additional to developing the aforementioned university courses, he has tutored a successful professional development short course in Microarray Bioinformatics run by Oxford University.
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Supplier and Vendor Location and Selection He has experience in sourcing high-performance computing solutions for laboratory research.
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Education
