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Expert in Biomedical Sciences, Vascular Biology, Angiogenesis
Available for your Consulting and Expert Witness Needs
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Summary of Expertise:
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Listed with other top experts in: |
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Expert completed his PhD in 1992 at St George's Hospital Medical School, on the microvascular parameters affecting post mastectomy lymphoedema in patients. After a year learning molecular biology at Glasgow University in Drosophila genetics, he spent three years as a postdoctoral researcher at the University of California at Davis, where he developed the existing single capillary cannulation technique to examine chronic regulation of permeability by growth factors, and started investigating VEGF signalling. He continued these studies as a lecturer at the University of Leicester, investigating the mechanism by which VEGF increases permeability using novel tyrosine kinase inhibitors. During that time he developed angiogenesis protocols to investigate VEGF signalling during blood vessel growth and moved to the University of Bristol as a BHF research fellow. In 2001 he was awarded a BHF lectureship, and in collaboration with Dr Steven Harper, a consultant nephrologist at Southmead Hospital, established the Microvascular Research Laboratories within the School of Veterinary Sciences. In that year he discovered the anti-angiogenic class of VEGF splice variants, and now investigates the potential of VEGF-splice variants, VEGF-induced angiogenesis and arteriogenesis, VEGF-receptor tyrosine kinase inhibitors, VEGF-activated ion channels and VEGF induced lymphatic metastasis. In 2007 he discovered, with Jacqui Shields that melanomas can metastasise through recognising chemokines secreted from lymphatics (metastatic chemotaxis), and that this occurs through CCL21/CCR7 interactions. In 2005 with Dr Neal, he discovered the sub-podocyte space of the kidney glomerulus, the first new urinary space in the kidney for 150 years. He was appointed Professor of Microvascular Biology and Medicine in the Department of Physiology and Pharmacology in Bristol in 2007.
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Show Secondary and Basic Areas of Expertise |
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Degree |
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Subject |
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Institution |
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1992
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PhD
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Physiology
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University of London
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1989
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BSc
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Zoology
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University of Newcastle upon Tyne
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| Years |
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Employer |
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Department |
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Title |
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Responsibilities |
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2007 to
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(Undisclosed)
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School of Physiology and Pharmacology
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Professor of Microvascular Biology and Medicine
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He is responsible for the academic, scientific, translational and educational progress of the Microvascular Research Laboratories within the School of Physiology and Pharmacology
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Associations/Societies
British Microcirculation Society,
The Microcirculatory Society,
The European Microcirculation Society,
The Physiological Society,
The American Physiological Society.
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Awards/Recognition
Dr Hans and Mrs Gertrude Hirsch Award, Fight for Sight. 2009.
British Heart Foundation Lectureship in Basic Biomedical Sciences (2006). Renewal of this highly competitive award to "non clinical researchers who have shown outstanding ability in carrying out original and independent research".
2004 Skin Cancer Research Fund 25th Anniversary Clinical Training Laboratory Award. The SCaRF awarded me £100,000 to help support research training for plastic surgeons in skin cancer. This was an ad hoc award to celebrate their 25th anniversary and was the only one of its kind made.
2004 Van Leeuwenhoek Outstanding Young Investigator Travel Award. European Society for Microcirculation.
2003 Christian Crone Outstanding Young Investigator Award, Microcirculatory Society.
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| Publications: |
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Publications and Patents Summary
104 published papers in peer reviewed journals, 1 patent awarded, 7 patent applications, four patents licensed.
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Selected Publications and Publishers
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- Cancer Research
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| Selected Consulting Examples: |
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Advising major pharmaceutical company on research, marketing and clincial applications of VEGF receptor tyrosine kinase inhibitor in cancer.
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Advising major pharmaceutical company on research, marketing and clinical applications of VEGF inhibitor in eye disease.
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Member of steering committee as the scientific expert for major drug company for clinical development of lead compound.
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2007 Invited Scientific Adviser to Global Experts Advisory Meeting for Pharmaceutical Industry partner. (Chicago, USA);
2006 Invited Scientific Adviser to Global Advisory Board for pharmaceutical company (New Orleans);
2006 Invited Scientific Adviser to pan-European Advisory Board of Retinal Specialists (Lisbon);
2005 Invited Scientific Adviser to UK pharmaceutical company Advisory Board.
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| Additional Skills and Services: |
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Training/Seminars
2010 Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee;
2010 International Podocyte meeting. Organising committee;
2010. Experimental Biology, Anaheim. Featured topic organiser “Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators;”
2008 European Microcirculation Congress, Budapest, International Advisory Board;
2008 Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee;
2007. World Congress on Microcirculation. Programme committee;
2007. European Vascular Biology Meeting. Organising committee;
2006. Experimental Biology, San Francisco. Regulation of glomerular filtration by the podocyte. Chair and Organiser;
2006. European Society for Microcirculation. Program committee;
2006. European Society for Microcirculation. Symposium organiser;
Local Organising Committee, European Microcirculation Society meeting, Exeter, 2002
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Education
