Expert Consulting and Expert Witness Services

Expert in Fermentation, Product Recovery, Bioprocess Scale-Up, Bioinformatics, Former ISO 9000 Auditor

Expert 717488

Expert in Fermentation, Product Recovery, Bioprocess Scale-Up, Bioinformatics, Former ISO 9000 Auditor

Available for your Consulting and Expert Witness Needs

Career Accomplishments

Consulting Services

Expert Witness

Market Research


Summary of Expertise:

Primary Expertise Areas: (links show more experts in each area)	Expertise Description:
ISO 9000 auditing expert	Expert is a former certified ISO 9000 auditor. Expert advises on productivity and quality assurance improvements, preparations for current Good Manufacturing Practices (cGMP) for FDA compliance. As an expert user of mainframes, minicomputers and microprocessors, he is familiar with the Capability Maturity Model (CMM) of the Software Engineering Institute. He is the person to call for validations of computer systems.
biochemical research expert biotechnology expert bioinformatics expert	Expert is an expert in the development of pharmaceutical and biotechnology processes. These processes pertain to antibiotics, enzymes, vitamins, amino acids, allergens, steroids, and their recovery. He served six weeks in Kazakstan as an International Exchange Service Corp. (IESC) Volunteer Executive, to analyze the operation of two huge but nearly paralyzed biotechnology companies. He proposed at the Pentagon integrated solutions for company restructuring in line with U.S. defense conversions interest. His proposed solutions provided focal points for discussions between Kazakstan and United States government departments. For his efforts he received a letter of appreciation from the Honorable Senator Bradley. Expert has also audited pharmaceutical operations in Israel, Scotland, and the United States.
biochemical process development expert	Through Expert's Firm (formerly Biomatic Associates), Expert services companies who need to acquire, assess, or rapidly and economically develop process technology or production capabilities. Expert is a biochemical engineer skilled in microbiology, biochemistry, experimental designs, statistical analyses, and statistical process control. Recent projects include crystallization of a paper company by-product, followed by patent application. He was also involved with a cost evaluation related to marketing a new pharmaceutical product.
scale-up expert chemical reactor scale-up expert pharmaceutical reactor expert pilot plant scale-up expert chemical-process flow chart expert	Expert is an expert in scale-up and is the author of a publication entitled "Scaling of Oxygen Mass Transfer in Agitated Fermentors." As a process development specialist and process engineer, he has guided work on over 40 commercial fermentation processes. He has scaled from volumes of 250 ml. shakeflasks to over 30,000 gallon production reactors. He designed a production method for enzyme deactivation using poisonous gas. He designed and installed equipment for spraydrying and fluidized bed drying, enzyme immobilization and agglomeration, as well as equipment for ultra and dia-filtration, chromatography, and lyophilization. Recently he determined for Union Camp Co. the cost of a new process. With limited information he established, via simulations and scale-up optimizations based upon linear programming, the size of required equipment.
computer integrated manufacturing expert manufacturing software expert	Expert has worked as a systems analyst with the online process control of adiabatic petroleum reforming reactors. He has over 20 years of experience using computers in a pharmaceutical and chemical manufacturing environments. He built, maintained, managed, and analyzed large relational databases for petroleum reforming and pharmaceutical manufacturing. He is the author of mainframe and copyright protected personal computer software used by major pharmaceutical companies for process change tracking in antibiotic production. His Quizer (c) and XY-tBase (c) software links product yields with indexed process documentation, provides quality assurance, and provides a method for validated uniform data entry, data retrieval, engineering calculations, profile averaging, and quick plotting for process visualization. This results in rapid process and yield improvements. The Quizer program, when used by Imcera in Terra Haute, Indiana, delivered a 28 percent antibiotic yield improvement within 8 months' time. The HTL, High Teach Linking Method Program (c), operational at the Professional Service Group associated with the New Jersey Labor Department, provides computer illiterates with off line internet job bank data search capabilities. Another version links job seekers with requirements of incoming jobs via pattern recognition of common skills.
pharmaceutical research and development expert pharmaceutical research expert	As a biochemical engineer, Expert made it possible for E.R. Squibb & Sons to rise from fifth to second place in the semi-synthetic penicillin market. The success was a result of his development of a stable low-cost production immobilized enzyme process, which helped eliminate competitors.
bioengineering expert pharmaceutical manufacturing expert pharmaceutical engineering expert	At Miles Laboratories Inc. he improved enzyme production. The Marshall division thereby became the most profitable operations of all of Miles' divisions. He expanded its plant capacity by 35% by fermenting in Europe, shipping of sterile bulk liquid concentrate via a three-week ocean transport, followed by product recovery and finishing in the United States. Here he designed and installed production facilities for production of dust-free detergent enzymes and for the production of immobilized glycoisomerase. He developed major process improvements for production of protease, amylase, pectinase, glyocsidase, glucoamylase, glucoisomerase enzymes used in the detergent, baking, brewery, food, animal fodder, and beverage industries. At Merck & Co. Inc. he doubled chephalosporin fermentation capacity within 2.5 years, using microbial, bioengineering, and computer skills, thereby contributing over $100 million to annual profits.
biotechnology process engineering expert biotechnology market research expert international technology transfer expert chemical processing plant design expert	Before Expert became Director of Biotechnology at John Brown Engineering and Constructors, he was involved in day-to-day operations of pharmaceutical, biotechnology, and chemical plant designs. He performed routine equipment sizing, line sizing calculations, and drew process and instrumentation flow diagrams. As director he was responsible for technology transfer, sales presentations, and project executions. He put the name of John Brown on the map of the United States. Since then, Expert has worked as a subcontractor for several engineering companies to assist them in detail design and engineering of Nutrasweet 1/2 (Aspartame), polymer, biopolymer, and genetic engineering plants.
computer-aided manufacturing expert software development tool expert	Expert is an accomplished computer programmer, skilled in the use of mainframe, minicomputer and microprocessor (PC) computers. He started out programming in FORTRAN, to solve his operational needs in pharmaceutical manufacturing using IBM mainframe computers under JCL control using MVS. He worked at Engelhard Industries with a GE 4020 on-line process mini-computer. Profits from biotechnology consulting are reinvented in multimedia software development tools to expand data retrieval of records to include retrieval of images based upon image content. Expert is currently studying subjects in chaos theory which involves finding the locations of stable pairs of non-linear dynamic systems. This led him to the study of Smale horseshoes, Cantor sets and Knot Theory, all of which are known to have made contributions to a better understanding of biological phenomena.
product recovery expert protein structure prediction expert
Show Secondary and Basic Areas of Expertise
*Localities:* Expert may consult nationally and internationally, and is also local to the following cities: Tampa, Florida; Saint Petersburg, Florida; Clearwater, Florida; Cape Coral, Florida; Lakeland, Florida; Largo, Florida; Boynton Beach, Florida; and Sarasota, Florida.

Education:

Year	Degree	Subject	Institution	Honors
1974	MBA	Finance	Fairleigh Dickinson University	Magna Cum Laude
1964	Ph.D.	Biochemistry	Cornell University
1962	M.Sc.	Chemical Engineering	Technical University, Delft, Holland
2001		Analysis of DNA and Protein Sequences	Rutgers University Audit course
2002		Homology Modeling of 3D Protein Structures	Rutgers University audit course (in process)

Work History:

Years	Employer	Department	Title	Responsibilities
1998 to	(Undisclosed Consulting Company)		President/Consultant/Multimedia Software Developer	As a consultant he resolves problems for client companies. At Expert's Firm, he researches inprovements in ab-initio 3D protein structure prediction methods.
1983 to 1997	Biomatic Associates		President/Consultant/Software Developer	As a biotechnology consultant he assisted many clients. Projects ranged from preparing bid packages for fermentor installations to auditing of operation and manufacturing facilities in Israel to research on bovine growth hormone production. As an engineering company subcontractor he was involved in detailed design of pharmaceutical facilities for production of biopolymers and artificial sweeteners.
1980 to 1982	John Brown Engineering & Constructors	Biotechnology Product Development	Director/Product Developer/Project Engineer	He started with detailed engineering design of chemical and pharmaceutical facilities. After he provided John Brown with an overview of the biotechnology world he drew the attention of the CEO and was promoted to director. In this function he guided the engineering staff and brought to the company necessary innovations in technology.
1976 to 1979	Merck & Co., Inc .	Antibiotic Process Development	Research Fellow	At Merck & Co., Inc. Expert filled three functions. He supervised operations and staff and renovated a fermentation laboratory. He provided technical service to two mefoxin antibiotic manufacturing plants. He wrote a manufacturing fermentation data retrieval program, maintained the database, and optimized manufacturing operations based upon analytical results obtained with programs FERMAV and DATRET. His department contributed $100 million/year to Merck's profits.
1971 to 1976	Miles Laboratories	Process Development and Process Engineering, Commercial Enzymes Manufacturing	Manager of Engineering and Process Research	Upon joining Miles Laboratories Expert quickly taught Miles scientists effective use of experimental designs aided by statistical analysis. This resulted in replacing a surface enzyme fermentation process by a much more economical submerged fermentation process. During his stay at Miles he introduced new first-of-its-kind technology, e.g., spray drying following ultrafiltration; prilling of detergent enzymes; partial replacement of malt by industrial enzymes in beer manufacturing; and, production of immobilized glucose isomerase enzyme.
1969 to 1970	Engelhard Industries Inc.	Research and Development	IT Systems Analyst	Expert assessed the present value of an installed process computer hooked up to a petroleum refining pilot plant. He advised management to extend the use of this computer to incorporate also a catalytic muffler operation project.
1964 to 1969	E. R. Squibb & Sons	Fermentation Research and Development Pilot Plant	Research Scientist	At E.R. Squibb Expert brought chemical and biochemical engineering expertise to a microbiological-oriented process development approach. He introduced experimental design and statistical analysis as a useful R&D tool. He divided his time between pilot plant operations with process scale-up into manufacturing, and programming of a manufacturing data retrieval system which he used for building a dynamic non-linear fermentation model, which he subsequently optimized by his fats "Generalized Separable Programming Methods". Without knowing it he implemented thereby a state variable feedback method which circumvented "the curse of the dimensionality."
1962 to 1964	Cornell University	Biochemistry	Teaching Assistant/ Research Assistant	Expert enjoyed teaching a class of graduate biochemistry students.

Career Accomplishments:

Associations/Societies

Expert was a member of the International Society a of Pharmaceutical Engineers and is a member of the American Chemical Society.

Professional Appointments

He is a past Chairman of the ACS Microbial and Biochemical Technology Division's membership committee. Additionally, he is an honorary member of the Dutch Birdbanding Society.

Awards/Recognition

Expert served six weeks in Kazakhstan as an International Executive Service Corp (IESC) volunteer. For his service in Kazakhstan Expert received a silver plate from the IESC. He also received a letter from The Honorable Senator Bill Bradley in appreciation of his service in Kazakhstan.

Government Experience:

Years		Agency		Role		Description
1995 to 1995		D.O.D.		IESC Volunteer Executive Consultant		Just before Expert traveled to Kazakhstan, Department of Defense personnel learned about Expert' travel plans. Expert was then invited to discuss at the Pentagon the interest of the Departments of Defense, State, and Commerce in providing former biological warfare scientists with continued employment opportunities. Upon his return he presented his view of what could and could not be accomplished and how this could be implemented.

Consulting Services:

Expert reviewed a tissue culturing process, and advised a pharmaceutical company on cost reduction methods. He determined the cost of a product manufacturing plant.

He supervised laboratory research in the production of a cholesterol-binding product from tall oil, and achieved required 90% purity by crystallization.

He advised a chemical engineering company in Volvograd, Russia on the design of hemicellulase derivative manufacturing technology.

As a member of the Intota consultant network, Expert is a specialist who provides technical consulting to corporate, legal and government clients. Expert provides professional consulting as a Fermentation Consultant, Product Recovery Consultant, Bioprocess Scale-Up Consultant, Bioinformatics Consultant, Former ISO 9000 Auditor Consultant. Expert may consult as an independent consultant or as a member of a consultancy, consulting company, or consulting firm. Consultants service will be covered by a consulting contract. Ask an expert initial screening questions and ask the experts services particulars, by simply submitting an expert request.

Expert Witness:

Intota experts can serve as expert witnesses or litigation consultants offering expert testimony, expert advice, litigation support, forensic services, and related expert witness services. Expert can serve as an expert witness or litigation consultant in intellectual property (patent, trademark, trade secret, copyright), product liability, and insurance matters. Expert may provide forensic expert witness testimony, litigation consulting services, forensic investigation, and forensic testing if appropriate in litigation areas as a Fermentation Expert Witness, Product Recovery Expert Witness, Bioprocess Scale-Up Expert Witness, Bioinformatics Expert Witness, Former ISO 9000 Auditor Expert Witness. Intota provides attorneys and legal professionals the opportunity to ask an expert initial screening questions and ask the experts services particulars by submitting an expert request.

International Experience:

Years	Country / Region	Summary
1994 to 1994	Israel, Scotland	Expert assisted a U.S. company with auditing biotech facilities and their cGMP and ISO 9000 operations.
1995 to 1995	Kazakhstan	As an International Executive Service Corp volunteer, he assisted two biotech companies in Kazakhstan. His recommendations became the focus point of discussions between the Kazakh and U.S. government agencies.
1999 to 1999	Russia	As a Citizen Democratic Corp volunteer, Expert assisted Volgograd engineering and construction and several chemical companies with technology improvement.

Language Skills:

Foreign Language		Description
Dutch		Expert is fluent in Dutch.
German		Expert is proficient in German.
French		Expert is proficient in French.
Russian, Latin, & Greek.		He is able to travel, communicate verbally, and get thoughts across in Russian. He studied Latin and Greek for five years, and read Ovid and De Bello Gallico in Latin, and Homer's Odyssae in Greek.

Market Research:

Expert participated in many sales presentations as the technical expert. As a result of his efforts Standard Brands selected John Brown Engineers and Constructors, Inc. for a $100,000 first phase project for construction of an alcohol by fermentation project. This was followed by many more bidding projects which resulted in a high percentage success ratio in obtaining biotechnology design and construction project awards.

Expert serves as a resource to Intota Market Research Services for customized marketing research in industries or areas related to Fermentation, Product Recovery, Bioprocess Scale-Up, Bioinformatics, Former ISO 9000 Auditor. Experts are an invaluable source of overall industry insight as well as insight into specific companies and firms for custom business to business (b2b) and industrial market research. Intota uses analyst and consultant resources from Guideline whose Research Directors manage the research and analysis of the qualitative and quantitative data as well as report writing for the custom studies. The methods and tools used by Intota market research combine the insights of technical experts and industry insiders with secondary research to provide the custom b2b and industrial market research you need.

Additional Skills and Services:

Supplier and Vendor Location and Selection

Expert has experience in locating vendors of: chemical, biotechnology, and pharmaceutical equipment; computer software and hardware; and high-technology items, e.g., parallel processors, Global Positioning Systems, and transputers. He has access to the following resources to aid in vendor location: twenty trade journals which he regularly reads, including: Pharmaceutical Engineering, Computer Design, AI Expert, NASA TECH Briefs, Software, Byte, PC Magazine, and Federal Reserve Bank Reviews. He also has access to publications, Rutgers' libraries, personal contacts, and the Internet.

Other Skills and Services

As a biochemist and microbiology expert, Expert has a gift to understand and simplify complicated mathematics. He knows to apply this knowledge in design and implementation of economically feasible projects.

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