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Expert in Peptide Synthesis
Available for your Consulting and Expert Witness Needs
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Summary of Expertise:
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Listed with other top experts in: |
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Expert has spent most of his career conducting research on the chemistry of the synthesis of peptides. He has experience with all the common methods of coupling, which includes carbodiimides, mixed anhydrides, and phosphonium salt-based reagents, and he has contributed to the elucidation of the mechanisms involved. He is responsible for establishing the existence of 2-alkoxy-5(4H)-oxazolones as intermediates in coupling reactions. He has served as consultant to a process development laboratory. He is writing a book for learners on peptide synthesis that includes the latest developments.
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Expert has devoted much of his research contributing to our understanding of the stereomutation that accompanies coupling reactions. He is the recognized authority in the field. He can provide the best advice as to how to minimize or eliminate the problem. Expert is responsible for introducing the more appropriate term enantiomerization instead of racemization, which is gradually being adopted by the peptide community.
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Expert has experience with the preparation and use of derivatives of nearly all the amino acids and has published research papers on the development of many of these methods. He serves as consultant to a retail producer/supplier of amino acid derivatives.
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Expert developed the modern chemistry of the difficult to handle N-methylamino acids. In 1973 he devised the simple method that is the current one for preparing synthetically useful derivatives of N-methylamino acids from the unmethylated derivative. He eliminated the misconception that N-methylamino acids are more chirally stable than unmethylated amino acids and established that it is the opposite. He has published a dozen research papers on mono-, di-, and trimethylation and has written review chapters on the subject.
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Expert has spent all of his career in the field of amino-acid and peptide chemistry. He is well acquainted with derivatization and reactions of amino groups and the preparation of methyl esters.
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Expert has extensive practical experience with reactions involving activation and derivatization of carboxylic acids, in particular the preparation of esters, hydrazides and amides of amino acids. This involved amongst other fundamental contributions on the chemistry of mixed anhydrides.
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Expert has experience in the separation, detection, and quantitation of enantiomers of amino acids, their derivatives and peptides, and the preparation of the single-isomer compounds. He has developed a method for converting a small peptide into the single-isomer form of its amide and methylamide via an active ester generated from a mixed anhydride.
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Expert has published numerous papers on the chemistry involved in the isomerization of amino acids and peptides and is an expert on the options available for minimizing it during the manipulation of these compounds.
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Expert has published numerous papers focussing on the changes in stereochemistry and their prevention that occur during the reactions involved in linking amino acid derivatives to form peptides.
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Show Secondary and Basic Areas of Expertise |
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Degree |
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Subject |
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Institution |
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1957
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PhD
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Biochemistry
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Universite de Montral
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1955
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MSc
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Biochemistry
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Universite de Montral
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1953
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BSc
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Chemistry
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(Magna Cum Laude) Loyola of Montreal
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| Years |
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Employer |
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Department |
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Title |
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1997 to
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(Undisclosed University)
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Biochemistry
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Professor Emeritus
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1994 to 1996
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(Undisclosed University)
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Department of Biochemistry
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Visiting Professor
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1993 to 1993
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ETH-Zurich
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Department of Chemistry
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Visiting Professor
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1987 to 1988
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Salk Institute, La Jolla, CA
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Visiting Scientist
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1980 to 1981
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MRC-Lab. Mol. Biol. Cambridge, UK
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Sabbatical Leave
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1972 to 1973
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Institute of Mol. Biol. Biophys., ETH-Zurich
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Sabbatical Leave
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1970 to 1994
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(Undisclosed University)
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Professor of Biochemistry,
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Associations/Societies
He is a member of the American Chemical Society, the American Peptide Society, and the European Peptide Society. He had also been a member of the Canadian Biochemical Society 1961-95, Royal Society of Chemistry (UK) 1968-93, and Biochemical Society (UK) 1968-93.
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Awards/Recognition
Expert received the prestigious Career Investigator of the Medical Research Council Award, which he held throughout his career. This personnel support initiative, with no new appointees after 1980, was established to help develop research programs in university medical schools.
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| Publications: |
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Selected Publications and Publishers
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- Canadian Journal of Chemistry
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| Selected Consulting Examples: |
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He served as consultant for the process design group of a large pharmaceutical company, three day-visits/year over two years.
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Served as an advisor on nomenclature and organization for design catalogue for retailer of amino-acid derivatives for synthesis.
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Click the green button above to contact
Expert for a free initial screening call regarding your expert consulting needs.
Expert is available for consulting to corporate, legal and government clients.
Remember, your initial screening call to speak with
Expert is free.
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Expert Witness Experience Summary:
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Expert has served as an expert witness assessing the contents of a patent for the defendee in a patent litigaion.
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Click the green button above to contact
Expert for a free initial screening call regarding expert testimony,
litigation consulting and support, forensic services, or any related expert witness services.
A few litigation needs include product liability, personal injury, economic loss, intellectual property
(patent, trademark, trade secret, copyright), and insurance matters. Remember, your initial screening
call to speak with
Expert is free.
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| International Experience: |
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Summary |
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Switzerland
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Expert was on a one-year leave of absence (1972-73) at the Institute of Molecular Biology of the ETH (Federal Institute of Technology) in Zurich. He also spent six months as a Visiting Professor (1993) at ETH's Laboratory of Organic Chemistry at the invitation of Professor D. Seebach.
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United Kingdom
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He was a Post-Doctoral Fellow (1958-60) at the University of Exeter's Department of Chemistry. He was also a Visiting Scientist (1980-81) at the Medical Research Council at Cambridge.
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| Language Skills: |
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| Foreign Language |
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Description |
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French
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Expert is fluent in French and reads and speaks scientific German at a basic level.
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German
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| Additional Skills and Services: |
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Training/Seminars
Expert has been lecturing on chemical aspects of biochemistry through much of his career (some in French). He has developed and presents a Short Course (two-day, 12h) on the Chemistry of the Synthesis of Peptides at the National Meetings of the American Chemical Society.
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Other Skills and Services
On-Site Consulting- Expert made on-site visits to the chemical and agricultural products division of a multi-national U.S. pharmaceutical company. In 1997, he made a one-day on-site visit to a pharmaceutical company in San Diego. Other Consulting Services - Expert has an informal arrangement as a consultant with a U.S. retailer of peptide synthesis starting materials. He has conducted a detailed analysis and revision of their recent product catalogue, in particular presentation of material and correctness of nomenclature.
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Education
