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Expert in Biochemistry, Cell Biology
Available for your Consulting and Expert Witness Needs
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| Summary of Expertise: |
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Primary Expertise Areas:
(links show more experts in each area)
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Expertise Description: |
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biochemistry expert
biochemical research expert |
For over 25 years, Expert has been actively engaged in biochemical research either at the bench or in supervising a research group of about 10 technicians, students, and post-doctoral fellows. His biochemical expertise deals with carbohydrates, lipids, proteins, glycoproteins, and polysaccharides. In addition, he is proficient in a variety of modern molecular biology approaches to address biochemical and cell biological questions. Most of the 95 peer-reviewed papers which he has published are in biochemical journals. |
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receptor biochemistry expert |
Expert has been directing a research program characterizing two liver specific membrane receptors involved in receptor mediated endocytosis and the clearance of several different carbohydrate-containing molecules. He has extensive experience characterizing the specificity and affinity of receptor interactions and subsequent internalization of receptor-ligand complexes. He is also familiar with characterizing the subunit composition of receptors as well as their purification, characterization, and cloning at the molecular level. Additionally, he is knowledgeable of site-directed mutagenesis approaches to studying the structure-function of receptors reconstituted in transfected cells. |
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cell (biology) expert
cell biology expert
cell physiology expert |
These areas are essentially identical and represent expertise that Expert has developed and strengthened in his laboratory research after his doctoral work. Many of his publications can be classified in this area. He has regularly attended and presented his research at the annual national meetings of the American Society for Cell Biology. Expert's laboratory has used a wide range of techniques in this area. These include electron microscopy, fluorescence microscopy, tissue (cell) culture, and liver cell preparation. |
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endocytosis expert |
Expert is an established expert in the field of receptor mediated endocytosis and has been publishing actively on this process as well as receptor characterization since 1980. He has had continuous NIH supported funding since 1979 for projects investigating the mechanisms controlling receptor mediated endocytosis and receptor recycling. A high percentage of his publications have dealt with these topics. |
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hyaluronic acid expert |
A significant portion of Expert's research has been devoted to biochemistry and the synthesis and degradation of hyaluronic acid. His group was the first in the world to clone the gene for the enzyme that allows Group A streptococcal bacteria to synthesize hyaluronic acid. They also have experience in studies dealing with the interaction between hyaluronic acid and fibrinogen and its effect on blood clotting, and they are studying other hyaluronic acid binding proteins and receptors that are physiologically significant. For example, the group is purifying and cloning a liver specific receptor that removes circulating hyaluronic acid from the blood. They also have expertise with unique chemical modifications of hyaluronic acid that allow them to make unusual and extremely useful probes to study its metabolism and interactions with cells. |
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cell surface interaction expert |
A small fraction of Expert's research effort and publications over the last 10 years has dealt with cell surface interactions. This has involved the preparation of chemically defined cell culture substrata and the examination of the mechanism by which cells can adhere to and spread on them. |
| Show Secondary and Basic Areas of Expertise |
Localities:
Expert may consult nationally and internationally, and is also local to the following cities: Oklahoma City, Oklahoma; Tulsa, Oklahoma; Norman, Oklahoma; Lawton, Oklahoma; Broken Arrow, Oklahoma; and Edmond, Oklahoma.
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Degree |
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Subject |
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Institution |
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1975
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Ph.D.
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Biochemistry
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The Johns Hopkins University School of Medicine
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1969
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M.A
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Biochemistry
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The Johns Hopkins University School of Medicine
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1968
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B.A.
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Chemistry
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Cornell University
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Department |
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Title |
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Responsibilities |
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1994 to
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(Undisclosed University)
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Department of Biochemistry and Molecular Biology
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Professor & Chairman
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Expert is the head of a basic science department with 22 faculty and 120 employees. He has also directed his own laboratory and research program funded by the NIH for over 22 years. In addition, he co-founded a biotechnology company in 2000, based in part on patents and intellectual property he developed.
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1978 to 1994
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University of Texas
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Human Biological Chemistry & Genetics
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Professor
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Expert joined the University of Texas Medical Branch at Galveston as an Assistant Professor in 1978 and became a Professor of Biochemistry and Cell Biology in 1987.
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Associations/Societies
Expert is an active member of the American Chemical Society, the American Society for Biochemistry and Molecular Biology, the Academy of Sciences, the American Society for Cell Biology, as well as many other professional societies.
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Professional Appointments
He is an Editorial Board member for the Journal of Biological Chemistry and is also a grant reviewer for the American Cancer Society, NSF, USDA, and the NIH. Expert was the recipient of a Postdoctoral Fellowship from the National Cancer Institute for the period 1975-78.
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Publications and Patents
He has published and presented more than 160 technical papers and is a manuscript reviewer for a number of technical journals, including Biochemistry, the Journal of Cell Biology, the International Journal of Cancer, and the Journal of Biological Chemistry. Additionally, Expert currently has five U.S. patents on the covalent immobilization of biomolecules on an inert chemically defined matrix and on the production of hyaluronan.
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Expert is presently a consultant for a new biotechnology company.
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He has been a Teltech consultant since 1986 and has participated in more than 40 client events.
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As a member of the Intota consultant network,
Expert is a specialist who provides technical consulting to corporate, legal and government clients. Expert provides professional consulting as a Biochemistry Consultant, Cell Biology Consultant. Expert may consult as an independent consultant or as a member of a consultancy, consulting company,
or consulting firm. Consultants service will be covered by a consulting contract.
Ask an expert initial screening questions and ask the experts services particulars, by simply submitting
an expert request.
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Intota experts can serve as expert witnesses or litigation consultants offering expert testimony, expert advice, litigation support,
forensic services, and related expert witness services. Expert can serve as an expert witness or litigation consultant in intellectual property (patent, trademark, trade secret, copyright),
product liability, and insurance matters. Expert may provide forensic expert witness testimony, litigation consulting services, forensic investigation,
and forensic testing if appropriate in litigation areas as a Biochemistry Expert Witness, Cell Biology Expert Witness.
Intota provides attorneys and legal professionals the opportunity to ask an expert initial screening questions and
ask the experts services particulars by submitting an expert request.
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Expert serves as a resource to
Intota Market Research Services
for customized marketing research in industries or areas related to
Biochemistry, Cell Biology.
Experts are an invaluable source of overall industry insight as well as insight into specific companies and firms for
custom business to business (b2b) and industrial market research. Intota uses analyst and
consultant resources from Guideline whose Research Directors manage the research and analysis of the qualitative
and quantitative data as well as report writing for the custom studies. The methods and tools
used by Intota market research combine the insights of technical experts and industry insiders with secondary
research to provide the custom b2b and industrial market research you need.
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| Additional Skills and Services: |
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Training/Seminars
Expert presents three to five seminars per year at universities and national or international meetings.
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Supplier and Vendor Location and Selection He has experience locating vendors of biochemical/cell biology reagents and equipment.
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Other Skills and Services
Expert has made substantial research contributions in several fields, including the discoveries of multiple coated pit pathways for receptor-mediated endocytosis and of the enzyme responsible for hyaluronan biosynthesis. He has had a long-standing interest in the biochemistry and the biology of hyaluronan. His group was the first to identify and isolate the gene for hyaluronan synthase. Expert's laboratory also developed the use of structurally defined iodinated hyaluronan oligosaccharides of high specific radioactivity to detect and to study specific hyaluronan receptors and binding proteins. This approach has recently enabled his laboratory to purify the liver endothelial cell receptor that removes circulating hyaluronan fragments from the blood by receptor-mediated endocytosis.
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Expertise
