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Expert in Free Radical Chemistry and Biology; Oxidation and Antioxidants
Available for your Consulting and Expert Witness Needs
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California (CA)
California
USA
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Summary of Expertise:
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Listed with other top experts in: |
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Expert has broad experience in the area of antioxidants for both chemical and biological/pharmaceutical applications. He has extensively investigated the mechanisms of antioxidant action, especially the mechanism of action of novel antioxidant compounds. He has developed methodology, including both oximetry and electron spin resonance (ESR) spin trapping, for accurately evaluating the chemical activity and effectiveness of antioxidants in complex systems.
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Expert has investigated the mechanisms of antioxidant action, especially in the context of membrane lipid peroxidation. He has studied not only traditional phenolic antioxidants, but novel antioxidant compounds based on nitrone, nitroxide, and pyrimidine chemistry. He has developed methodology, including both oximetry and electron spin resonance (ESR) spin trapping, for accurately evaluating the chemical activity and effectiveness of antioxidants in complex systems.
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Expert is currently studying the detailed chemical mechanisms for oxidation of biological substrates, particularly membrane lipids. These studies have included the determination of oxidative damage in various biological tissues using the electron spin resonance spin-trapping technique. His research has also involved the development of models for biological membrane lipid oxidative damage in order to accurately evaluate the efficacy of antioxidant compounds.
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Expert has made extensive use of the electron spin resonance spin-trapping technique for studying gas-phase free radicals. He has developed techniques for the detection, quantitation, and partial identification of reactive organic radicals in complex gas-phase mixtures, including tobacco smoke, smoke from burning natural and man-made materials, and thermal decomposition of perfluoropolymers. His major interest in these studies has been the relationship between the toxicity of these various combustion gases and their free-radical content.
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Electron paramagnetic resonance (EPR) spectroscopy is one of the principal techniques used by Expert to study free radical mechanisms in chemical and biological systems. He has developed computer techniques for the analysis of complex EPR spectra. He has also used both digital and analog methods for the enhancement of signal-to-noise and is currently studying new techniques of weak-signal detection. Expert is an expert in the use of the spin-trapping technique in studies of reactive species. The systems he has studied range from gas-phase models for polluted air to biological systems, including whole animal models. He has also used the spin labeling technique to study the effects of membrane lipid oxidation and of antioxidants on membrane characteristics. Expert is using electron spin resonance spectroscopy to study both stable and highly reactive organic free radicals. He is an expert in the use of the spin-trapping technique in studies of reactive species. The systems he has studied range from gas-phase models for polluted air to biological systems, including whole animal models. He also has considerable experience with the design of novel nitrone spin traps.
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Expert has more than 20 years of experience in many areas of free-radical chemistry. This work includes studies of the oxidation of organic and biological compounds, both by ozone as well as in autoxidation, the scavenging of reactive free radicals, gas-phase free radicals (polluted air and cigarette smoke), the detection of reactive free radicals using electron spin resonance spectroscopy, single-electron transfer reactions, and mechanistic studies using kinetics and linear-free energy relationships.
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Expert is highly experienced in all aspects of lipid peroxidation. He has specific experience with lipid peroxidation in organized media and on its inhibition with antioxidants. He has developed model systems that accurately predict the activity of natural and synthetic antioxidants in membrane bilayers. He has special experience in monitoring lipid peroxidation using ESR spectroscopic techniques.
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Having extensive experience with antioxidants, Expert can answer in-depth questions on vitamins A, C, and E. He has investigated the mechanisms by which these antioxidants inhibit membrane lipid peroxidation. He has developed methodology, including the use of ESR spectroscopy, for accurately evaluating the chemical activity and effectiveness of antioxidants in the membrane bilayer environment.
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Expert has expertise in the chemistry of ozone, both in solution and in the gas-phase. He is particularly experienced with those aspects of ozone reaction mechanisms that result in the formation of free-radical intermediates. He has applied ESR spin-trapping technology to the study of radicals formed from the reaction of ozone with various organic and biological substrates. Expert has also used this technology to study the formation of free radicals during ozonization reactions of various chemical and biological substrates. He has been special expertise in the area of the relationship between the toxicity of ozone from polluted air and its free radical chemistry.
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A major area of research activity by Expert is the mechanism of antioxidant action in controlling membrane lipid peroxidation. He has a great deal of experience in the antioxidant behavior of tocopherol, especially in motion-restricted environments such as biological membranes. An important part of these studies has been the development of methodology, including both oximetry and ESR spin trapping, for accurately evaluating the chemical activity and effectiveness of antioxidants in the membrane environment.
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Expert has studied changes in membrane characteristics using ESR spin labels. He has focused on how components associated with lipid peroxidation and antioxidants modify membrane fluidity, and how this relates to antioxidant activity in the membrane environment.
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Expert has extensively studied the free radical chemistry of tobacco smoke. He has developed methods for detection of free radical components using ESR techniques (both direct and spin trapping). He has developed a remarkably accurate model for the production of reactive radical species in gas phase smoke. He has written a number of reviews relating the free radical chemistry of cigarette smoke to the health effects of smoke.
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Show Secondary and Basic Areas of Expertise | Localities:
Expert may consult nationally and internationally, and is also local to the following cities: San Jose, California;
San Francisco, California;
Sacramento, California;
Oakland, California;
Stockton, California;
Fremont, California;
Santa Rosa, California;
Hayward, California;
Sunnyvale, California;
and Concord, California.
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Degree |
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Subject |
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Institution |
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1976
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Ph.D.
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Organic Chemistry
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Oregon State University
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1971
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B.A.
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Chemistry
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Macalester College
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Employer |
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Title |
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Responsibilities |
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1996 to
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(Undisclosed)
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1983 to 1996
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Louisiana State University
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Various (please see Responsibilities section)
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Associate Professor, 1992-96.
Associate Professor, Research, 1990-92.
Assistant Professor, Research, 1983-90.
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Associations/Societies
Expert is a member of the American Chemical Society, the American Oil Chemists Society, the International EPR Society, and the Oxygen Society.
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| Publications: |
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Publications and Patents Summary
He has more than 130 publications.
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Selected Publications and Publishers
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- Analytical Chemistry
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- Free Radical Biology & Medicine
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- Chemical Research in Toxicology
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- Raven Press
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- Oxidative Damage and Repair: Chemical, Biological, and Medical Aspects, Pergamon Press
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| Selected Consulting Examples: |
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Expert has served on NIH panels reviewing program project proposals.
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He has carried out on-site toxicological analyses for free radical damage.
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Recent Client Requests:
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Expert in antioxidants for consulting on uses in pharmaceutical tablets.
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Click the green button above to contact
Expert for a free initial screening call regarding your expert consulting needs.
Expert is available for consulting to corporate, legal and government clients.
Remember, your initial screening call to speak with
Expert is free.
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Recent Litigation Client Requests:
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Expert in vitamin A toxicity for consulting in product liability case.
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Click the green button above to contact
Expert for a free initial screening call regarding expert testimony,
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A few litigation needs include product liability, personal injury, economic loss, intellectual property
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Expert is free.
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Education
