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Expert in Controlled Release, Microencapsulation, Drug delivery, Taste Masking, Bioavailability Enhancement
Available for your Consulting and Expert Witness Needs
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Summary of Expertise:
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Listed with other top experts in: |
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Expert has almost ten years of experience in the formulation of pharmaceuticals for controlled release delivery. This work includes tastemasking, enteric protection, colonic delivery, drug bioavailability enhancement, prevention of ingredient interaction, nasal delivery, and buccal delivery. He has employed various coating and encapsulation methods including spray drying and developed new techniques for controlling release kinetics. He co-authored a recently published book chapter on microencapsulation in a text on coating for the series Pharmaceutical Unit Operations. Expert is familiar with a number of alternate techniques for microorganism encapsulation but has practiced this using spray drying and spray chilling methods using modified techniques and additives to maintain high viability.
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Expert has been involved in the formulation and process development for flavor and food additive microencapsulation using modified spray drying, spray chilling, pan coating, and fluid bed coating techniques. Applications have included improved particle size distributions, prevention of losses of more volatile components, improved bioavailability of nutritional supplements, prevention of ingredient interactions in storage, tastemasking of vitamin or mineral components, and stabilization of ingredients to process conditions. Expert has worked to build varying release kinetics into the formulations. He is familiar with most of the latest food ingredients, including the new, modified starches and uses for various gums and process aids. He has made dramatic improvements in the area of improved delivery and bioavailability of nutrition supplements, many of which are patentable.
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Expert has carried out a variety of liquid encapsulation techniques (both organic or inorganic), including spray drying, spray chilling (dispersions of liquids in melts), interfacial polymerization, and urea formaldehyde resin techniques. He is familiar with and has performed each of these techniques and knows their individual strengths and drawbacks as well as many of the operational tricks that are not always readily available in the literature. He has conducted solid encapsulations using fluid bed coating, spray chilling, spinning disk coating, as well as several other techniques. Expert has co-authored several book chapters with reviews of many of these techniques. He understands the right questions to ask and knows the parameters that must be understood in order to design the proper encapsulation technique or delivery system.
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Often more difficult than one might suspect, Expert has extensive experience with tastemasking. Factors such as size of dose, the nature of the taste sensation, the solubility of the particular active ingredient, the available form (powder, crystal), the need for a particular release profile, the delivered dosage form (suspension, sprinkles, fast release tablet, etc.) and the required amount of dose can all weigh into the decisions as to how to proceed with a development effort. He has experience in masking the taste of some of the most foul antibiotics, analgesics, and nutritional supplements, as well as some excipient materials.
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Expert has operational familiarity with Niro, Anhydro, Bowen, and Drytec spray dryers. He has developed formulations in the laboratory and carried the formulations through pilot trials and into production. He has successfully developed formulations in the area of foods, pharmaceuticals, cosmetics, nutritional supplements, agricultural chemicals, bacteria, and enzymes. Expert has modified atomizers, drying chambers, outlet configurations, etc. to successfully complete the drying development. He also developed formulations that allowed successful drying where other groups had failed to obtain a flowable or viable product. He has been invited to present this topic at industrial short courses on spray drying given in both the US and Europe.
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Show Secondary and Basic Areas of Expertise | Localities:
Expert may consult nationally and internationally, and is also local to the following cities: Saint Louis, Missouri;
Columbia, Missouri;
Saint Charles, Missouri;
Saint Peters, Missouri;
Florissant, Missouri;
and Springfield, Illinois.
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Degree |
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Subject |
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Institution |
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1975
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Post Doctoral Studies completed
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Pharmacy
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Ohio State University, Pharmacy College
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1974
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PhD
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Organic Chemistry (Molecular Biochemistry Minor)
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The Johns Hopkins University
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1970
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BS
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Chemistry
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Drexel University
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Employer |
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Department |
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Title |
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Responsibilities |
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2007 to 2009
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KV Pharmaceutical
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Research & Development
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Director of Drug Delivery Technology
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He directed development of several generic formulations as well as having a team for the development of new drug delivery technologies using nanoparticle techniques and emulsion technology. Other technologies were examined including gastro-retentive dosage forms and transdermal technologies. He also was responsible for technical assessment of outside technologies for possible licensing and looking at possible formulations to address unmet medical needs.
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1994 to 2007
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Particle and Coating Technologies, Inc.
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Director, Chemical Technology
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Directed day-to-day operations of the company including presentations to clients, proposals, experimental design, supervision of experimental studies and reporting.
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1989 to 1994
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Washington University, Chemical Engineering Department
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Research Associate
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He supervised research in a group doing contract research including students and full-time technicians as well as assisting in experimental design with gradualte students.
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1981 to 1989
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Petrolite Corporation
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Senior Chemist/Specialist
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Formulations research specialist
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1979 to 1981
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Ingersoll Rand
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Training Supervisor
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1975 to 1979
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Rockhurst College
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Assistant Professor
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1965 to 1970
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U.S. Navy R&D Laboratory
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Student Trainee
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Associations/Societies
Expert is a member of the American Chemical Society, the Controlled Release Society, the American Association of Pharmaceutical Scientists.
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Awards/Recognition
Expert was nominated as Danforth Scholar in 1979 in recognition for teaching and scholarly research while at Rockhurst College.
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Publications and Patents Summary
Expert has two U.S. patents, one in the area of encapsulation and the other in oilfield applications.
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Selected Publications and Publishers
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- Pharmaceutical Unit Operations-Coating. Interpharm Press, pp. 177-218. Buffalo Grove, Illinois
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- Polymeric Delivery Systems. ACS Symposium Series 520. American Chemical Society, Washington, D.C.
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- Marcel Dekker
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| Selected Consulting Examples: |
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Expert has been able to suggest new formulations or process conditions that have been implemented. Modification of techniques outside the norm were successful where on-site personnel would have sworn it was not going to work.
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Expert is often called on to advise whether a controlled release technique is in fact, necessary and if so provide some approaches to solving the particular problems.
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Recent Client Requests:
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Expert in spray drying toll work new york for consulting on Moringa leaf powder spray drying.
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Expert soluble coffee for consulting on coffee.
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Micro encapsulation expert for consulting on the refinement, concentration and micro encapsulation of Omega 3 bearing fish oil for use in functional food applications.
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Expert in Spray drying microcapsules.
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Click the green button above to contact
Expert for a free initial screening call regarding your expert consulting needs.
Expert is available for consulting to corporate, legal and government clients.
Remember, your initial screening call to speak with
Expert is free.
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Expert Witness Experience Summary:
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Expert has been called as a witness and has given depositions in a law suit involving patent infringement.
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Recent Litigation Client Requests:
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Pharmaceutical manufacturing expert for trade secret litigation case.
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Expert in tablet formulation to prepare APAP tablet pursuant to formulation in lab notebook.
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Food technology expert for consulting on determining the release of diacetyl in an encapsulated flavor.
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Click the green button above to contact
Expert for a free initial screening call regarding expert testimony,
litigation consulting and support, forensic services, or any related expert witness services.
A few litigation needs include product liability, personal injury, economic loss, intellectual property
(patent, trademark, trade secret, copyright), and insurance matters. Remember, your initial screening
call to speak with
Expert is free.
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| International Experience: |
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Summary |
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United Kingdom, Germany, The Netherlands, France
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United Kingdom: Expert conducted numerous plant trials, business presentations, and research laboratory consultations. He supervised short-term laboratory development efforts.
Germany: He was involved with a major plant trial at a large site and a laboratory pilot trial. He also made technical presentations. The Netherlands: Expert made numerous technical presentations and conducted laboratory consulting in the Netherlands. France: While in France, Expert was active in two pilot trials, including work with the installation of equipment and on-site formulation development. He made several technical presentations.
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In oil well stimulation chemicals, Expert worked in technical services and as a technical liaison, speaking to well service companies and oil company research laboratories.
Click the green button above to contact
Expert for a free initial screening call regarding your marketing research, industry research, and company
research needs. For research needs involving multiple experts or secondary research,
a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker
and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.
Remember, your initial screening call to speak with
Expert is free.
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| Additional Skills and Services: |
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Training/Seminars
Expert has given on-site seminars approximately three to four times a year for last several years.
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Supplier and Vendor Location and Selection Expert has experience locating vendors of the following:
* Contract spray drying/spray chilling (American Custom Drying, Drytec, Ltd.)
* Contract research in microencapsulation (Particle and Coating Technologies).
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Education
